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This medication is a combination of 2 antibiotics. It is used to treat certain serious bacterial infections that have not responded to treatment with other antibiotics (resistant infections). This medication belongs to the class of antibiotics called streptogramins. Quinupristin/dalfopristin works by stopping the growth of bacteria.
This medication is given by injection into a vein as directed by your doctor, usually 2 to 3 times daily (every 8 to 12 hours). It should be injected slowly over 1 hour. The dosage is based on your medical condition, body weight, and response to treatment.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same time(s) every day.
Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.
Tell your doctor if your condition persists or worsens.
Nausea, vomiting, diarrhea, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Tell your doctor right away if you develop redness/swelling/pain/warming of the skin at the injection site. Flushing the IV line after each dose of this medication with dextrose 5 percent in water solution as directed will reduce the risk of vein irritation.
Tell your doctor right away if you have any serious side effects, including: joint/muscle pain, yellowing eyes/skin, blood in the urine.
Get medical help right away if you experience this rare but very serious side effect: chest pain.
This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.
Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Before using quinupristin/dalfopristin, tell your doctor or pharmacist if you are allergic to it; or to other streptogramin antibiotics (e.g., pristinamycin, virginiamycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, high levels of bilirubin in the blood (hyperbilirubinemia).
This medication may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.
See also How to Use.
This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include certain antiarrhythmic drugs (e.g., amiodarone, disopyramide, quinidine), cisapride, cyclosporine, certain macrolide antibiotics (e.g., erythromycin, clarithromycin), certain antipsychotics (e.g., haloperidol, pimozide), among others.
Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.
Laboratory and/or medical tests (e.g., liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.