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Evolocumab is used to help lower "bad" cholesterol (LDL) in the blood. For people who have a certain inherited condition that causes high levels of LDL (heterozygous familial hypercholesterolemia) or who have blockage in the heart blood vessels, it is used along with a proper diet and a "statin" drug in the highest amount they can take. For people who have a different inherited condition that causes high levels of LDL (homozygous familial hypercholesterolemia), it is used along with a proper diet and other LDL-lowering treatments (such as "statin" drugs, ezetimibe, LDL apheresis). Evolocumab belongs to a class of drugs known as monoclonal antibodies. It works by improving how well your body gets rid of LDL cholesterol.
In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.
Read the Patient Information Leaflet if available from your pharmacist before you start using evolocumab and each time you get a refill. Carefully read and learn the Instructions for Use. If you have any questions, ask your doctor or pharmacist.
Before use, take evolocumab out of the refrigerator. If you are using the prefilled syringe/pen, let it warm up to room temperature for at least 30 minutes. If you are using the on-body infusor, let it warm up to room temperature for at least 45 minutes. Do not heat this medication any other way, such as by heating in the microwave or placing in hot water. Do not shake this medication. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.
Inject this medication under the skin of the thigh, abdomen, or upper arm as directed by your doctor, usually once every 2 weeks, or once every month. The dosage is based on your medical condition and response to treatment. If your doctor has prescribed the monthly dose and you are using the prefilled syringe/pen, you will use 3 separate injections within 30 minutes. If you are using the on-body infusor, the medication is injected over 9 minutes.
Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Do not inject into any areas of skin that are injured, tender, hard, red, or hot.
Use this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive the medication.
Learn how to store and discard medical supplies safely.
Redness, pain, or bruising at the injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Before using evolocumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex or dry natural rubber found in the needle cover on the prefilled syringe/pen) which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
Store in the original package in the refrigerator away from light and moisture. Do not freeze. If you keep this medication at room temperature, make sure to use it within 30 days and keep it in the original package. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
If you miss a dose, use it as soon as you remember if it is within 7 days from the missed dose. If it is longer than 7 days from the missed dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
Do not share this medication with others.
Lab and/or medical tests (such as LDL cholesterol levels) should be done while you are using this medication. Keep all medical and lab appointments.