Before taking this product, tell your doctor or pharmacist if you are allergic to orphenadrine, aspirin, or caffeine; or to other nonsteroidal anti-inflammatory drugs-NSAIDs (such as ibuprofen, naproxen, celecoxib); or to other salicylates (such as choline salicylate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: high pressure in the eye (glaucoma), stomach/intestine/esophagus problems (such as ulcers, blockage, difficulty swallowing, heartburn), difficulty urinating (such as due to enlarged prostate), a certain type of muscle/nerve disease (myasthenia gravis), asthma (including a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), growths in the nose (nasal polyps), bleeding/blood clotting problems (such as hemophilia, thrombocytopenia), gout, heart problems (such as fast/irregular heartbeat, heart failure, heart attack), high blood pressure, kidney disease, liver disease, mental/mood disorders (such as anxiety, nervousness), certain enzyme deficiencies (such as pyruvate kinase or G6PD deficiency).
This drug may make you dizzy or drowsy or cause blurred vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Before having surgery or certain medical procedures (such as a heart stress test or a procedure to restore a normal heart rhythm if you have an unusually fast heartbeat), tell your doctor or dentist that you use this medication and about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this product, may increase your risk for stomach bleeding. Limit alcoholic beverages and stop smoking. Consult your doctor or pharmacist for more information.
This drug contains aspirin. Children and teenagers younger than 18 years should not take aspirin if they have chickenpox, flu, or any undiagnosed illness or if they have recently received a vaccine. In these cases, taking aspirin increases the risk of Reye's syndrome, a rare but serious illness.
Older adults may be more sensitive to the side effects of this drug, especially confusion, stomach ulcer/bleeding, constipation, drowsiness, or trouble urinating. Confusion and drowsiness can increase the risk of falling.
Aspirin is not recommended for use during pregnancy. Consult your doctor before using this medication if you are or think you may be pregnant. Tell your doctor right away if you become pregnant or think you may be pregnant while taking this medication. Do not use this medication during the last 3 months of pregnancy because of possible harm to the unborn baby or problems during delivery.
This medication passes into breast milk and may harm a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.