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This medication is used by people with Parkinson's disease to treat one of its symptoms, uncontrolled movement disorder (dyskinesia). Parkinson's disease is caused by lack of a certain substance (dopamine) in the brain. Treatment usually includes medications that increase dopamine or act like dopamine. Amantadine may be used with or without these medications. This medication is thought to work by restoring the balance of certain natural substances (neurotransmitters) in the brain.
Take this medication by mouth with or without food as directed by your doctor, usually once daily at bedtime. Swallow the capsules whole. Do not crush or chew the capsules. Doing so can release all of the drug at once, increasing the risk of side effects. If you have trouble swallowing the capsule whole, you may open it and sprinkle the contents on a small amount of soft food (such as applesauce) just before taking. Swallow the mixture right away without chewing. Do not save it to take later.
The dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Do not stop taking this medication without consulting your doctor. Your condition may get worse if this drug is suddenly stopped or if your dose is quickly decreased. Your doctor may gradually reduce your dose to lessen the chance of symptoms such as agitation, anxiety, hallucinations, depression, or slurred speech. Tell your doctor right away of any new or worsening symptoms.
This medication may not work as well after you take it for several months. Talk with your doctor if this medication stops working well.
Amantadine may take several weeks to have an effect. Tell your doctor if your condition does not get better or if it gets worse.
Blurred vision, nausea, loss of appetite, drowsiness, dizziness, lightheadedness, headache, dry mouth, constipation, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Dizziness and lightheadedness can increase the risk of falling. Get up slowly when rising from a sitting or lying position.
To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: purplish-red blotchy spots on the skin (especially on the legs), swelling of the ankles/feet, difficulty urinating, vision changes, unusual strong urges (such as increased gambling, increased sexual urges, uncontrolled spending), mental/mood changes (such as anxiety, depression, hallucinations, suicidal thoughts/attempts), muscle spasms.
Get medical help right away if you have any very serious side effects, including: seizure.
Some people taking amantadine have fallen asleep suddenly during their usual daily activities (such as talking, driving). You might fall asleep without warning or without feeling drowsy. This effect can happen at any time even if you have used this medication for a long time. If you have increased sleepiness or fall asleep suddenly during the day, tell your doctor right away. Your risk is higher if you drink alcohol or take other medications that can make you drowsy. Do not drive or do other activities for which you need to be alert (see also Precautions section).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before taking amantadine, tell your doctor or pharmacist if you are allergic to it; or to rimantadine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, kidney disease, mental/mood conditions (such as depression, psychosis), a certain skin disorder (eczematoid dermatitis), sleep disorders (such as narcolepsy), seizure disorder.
This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of this drug, especially dizziness, lightheadedness, and mental/mood changes (such as hallucinations). Dizziness and lightheadedness can increase the risk of falling.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult with your doctor before breast-feeding.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Amantadine may interfere with the effect of certain vaccines, such as flu vaccine inhaled through the nose. However, you may have flu vaccine given by injection if recommended by your doctor.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include fast/irregular heartbeat, severe drowsiness, shortness of breath, change in the amount of urine, mental/mood changes (such as anxiety, aggression, confusion, hallucinations), seizure.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Do not share this medication with others.
People with Parkinson's disease may have an increased risk for developing skin cancer (melanoma). Tell your doctor promptly if you notice a change in the appearance or size of moles or other unusual skin changes. Ask your doctor if you should have regular skin exams.
Selected from the Licensed Solutions data included with permission and copyrighted by FDB, inc., 2014. This copyrighted material has been downloaded and Licensed data provider and is not for distribution in professional healthcare settings. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking any drug or commencing or discontinuing any course of treatment.