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This medication is used to provide protection (antibodies) against certain virus infections (hepatitis A, measles, chickenpox, rubella) in people who have not been vaccinated or have not had the infection before. It is also used to strengthen the body's natural defense system (immune system) to lower the risk of infection in persons with a certain immune system problem (immunoglobulin deficiency). This medication is made from healthy human blood that has high levels of certain defensive substances (antibodies), which help fight infections. Routine vaccination is usually the best way to protect against infection. Talk with your doctor about a recommended vaccination schedule.
This medication is injected into a muscle as directed by your doctor. The dosage and schedule of injections depends on your medical condition, weight, and response to treatment. Large doses (more than 10 milliliters) should be divided into 2 or more injections and given at separate injection sites.
This medication is given as soon as possible after you have had contact with (been exposed to) someone with hepatitis A, measles, chicken pox, or rubella. If you wait too long after being exposed, the medication may not be effective. Not everyone who is exposed to these infections should receive immunoglobulin. Discuss the risks and benefits with your doctor.
If you are traveling to an area where hepatitis A is common, this medication may be given along with the hepatitis A vaccine (in a separate injection). This medication will help protect you until your body can make antibodies from the vaccine. If you cannot use the hepatitis A vaccine, you may need to receive more doses of immune globulin if you are staying in the area for a long time (more than 3 months). Do not receive live virus vaccines (such as measles vaccine) at the same time as immune globulin. (See also Precautions section.) Ask your doctor or pharmacist for more details and a recommended vaccination schedule.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
If you are using this medication for an immune system problem, it is usually given every 3 to 4 weeks or as directed by your doctor. Use this medication regularly in order to get the most benefit from it. Keep all your medical/lab appointments.
See also Warning section.
Muscle stiffness, redness, warmth, pain, and tenderness at the injection site may occur. Fever, chills, headache, and joint pain may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: unusual tiredness, signs of kidney problems (such as change in the amount of urine, pink/bloody/frothy urine), sudden weight gain.
Rarely, this product may contain substances that could cause infections because it is made from human blood. Though the risk is very low due to careful screening of blood donors, discuss the risks and benefits with your doctor. Tell your doctor right away if you develop any signs of infection such as persistent sore throat/fever, yellowing eyes/skin, or dark urine.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
See also Warning section.
Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to other immunoglobulin products (such as IVIG); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain immune system problem (immunoglobulin A deficiency), bleeding/blood clotting problems (such as low platelets, hemophilia), kidney disease.
Tell your doctor of any recent or planned immunizations/vaccinations. This medication may prevent a good response to certain live viral vaccines (such as measles, mumps, rubella, varicella). If you have recently received any of these vaccines, your doctor may have you tested for a response or have you vaccinated again later. If you plan on getting any of these vaccines, your doctor will instruct you about the best time to receive them so you get a good response.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Store in the refrigerator between 36-46 degrees F (2-8 degrees C). Do not freeze. Discard any unused portion. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
See also Warning section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: drugs that may harm the kidneys (including aminoglycosides such as gentamicin).
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Because this medication provides protection for only a limited time (1 to 3 months), additional doses may be necessary based on the situation. Discuss this with your doctor.
Do not share this medication with others.
Laboratory and/or medical tests (e.g., kidney function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
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