Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: colchicine, eletriptan, ergot alkaloids (such as ergotamine, dihydroergotamine), digoxin, certain drugs for seizures (anti-convulsants such as carbamazepine, phenytoin, valproate), warfarin.
Many drugs besides erythromycin and those listed above may affect the heart rhythm (QT prolongation), including amiodarone, cisapride, disopyramide, dofetilide, gatifloxacin, moxifloxacin, pimozide, procainamide, propafenone, quinidine, sotalol, and thioridazine, among others. Therefore, before using erythromycin, report all medications you are currently using to your doctor or pharmacist.
This drug can slow down the removal of other drugs from your body by affecting certain liver enzymes. Some examples of these affected drugs include alfentanil, bromocriptine, buspirone, certain benzodiazepines (alprazolam, midazolam, triazolam), caffeine-containing drugs, cilostazol, corticosteroids (e.g., prednisone), eplerenone, certain drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), eszopiclone, felodipine, hexobarbital, certain "statin" drugs (such as lovastatin, simvastatin), quetiapine, tacrolimus, tolterodine, vinblastine.
Other medications can affect the removal of erythromycin from your body, which may affect how erythromycin works. Examples include azole antifungals (such as itraconazole, fluconazole), rifamycins (such as rifabutin), quinupristin-dalfopristin, saquinavir, calcium channel blockers (such as diltiazem, verapamil), among others.
This medication may interfere with certain laboratory tests (including urinary catecholamines), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.