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Brolucizumab is used to treat a certain serious eye condition (wet age-related macular degeneration). This medication can help preserve vision and prevent blindness. Brolucizumab belongs to a class of drugs known as growth factor inhibitors. It works by slowing the growth of abnormal new blood vessels in the eye and decreasing leakage from these blood vessels.
This monograph is about the following brolucizumab products: brolucizumab, brolucizumab-dbll.
This medication is given by injection into the affected eye(s) by a health care professional. The affected eye is numbed before each injection. After the injection, you will remain in the doctor's office for a while, and your eye(s) and vision will be monitored.
The dosage and treatment schedule are based on your medical condition and response to treatment. Your doctor will give you regularly scheduled injections, usually once a month for the first 3 doses, then every 8 to 12 weeks.
Use this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive this medication.
Tell your doctor if your condition does not get better or if it gets worse.
Injection site pain, feeling as if something is in the eye, or increased tears may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: floaters (blurry shapes that seem to float in front of your eyes), swollen eyelids.
Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, trouble speaking, confusion.
This medication may rarely increase your risk for developing certain serious eye conditions (endophthalmitis or retinal detachment). Get medical help right away if you notice any of these symptoms in the affected eye(s): pain, redness, sensitivity to light, blurred vision, sudden change in vision, decreased vision.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using brolucizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: current eye infection.
This drug may cause blurred vision. Do not drive, use machinery, or do any activity that requires clear vision until you can do it safely.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using brolucizumab. Brolucizumab may harm an unborn baby. Women of childbearing age should ask about reliable forms of birth control while using this medication and for at least 1 month after the last dose. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for at least 1 month after the last dose is not recommended. Consult your doctor before breast-feeding.
Not applicable. This medication is given in a hospital or doctor's office and will not be stored at home.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Overdose is unlikely with brolucizumab since it is given by a health care professional. However, if someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor right away for a new dosing schedule.
Your doctor will do regular eye exams to monitor your progress and check for side effects. Keep all medical and lab appointments.
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